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- Title
A new automated method versus continuous positive airway pressure method for measuring pressure-volume curves in patients with acute lung injury.
- Authors
Piacentini E; Wysocki M; Blanch L; Piacentini, Enrique; Wysocki, Marc; Blanch, Lluis
- Abstract
<bold>Objective: </bold>To compare pressure-volume (P-V) curves obtained with the Galileo ventilator with those obtained with the CPAP method in patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS).<bold>Design: </bold>Prospective, observational study.<bold>Setting: </bold>General critical care center.<bold>Patients and Participants: </bold>Patients with ALI/ARDS and receiving mechanical ventilation.<bold>Interventions: </bold>Pressure-volume curves were obtained in random order with the CPAP technique and with the software PV Tool-2 (Galileo ventilator).<bold>Measurements and Results: </bold>In ten consecutive patients, airway pressure was measured by a pressure transducer and changes in lung volume were measured by respiratory inductive plethysmography. P-V curves were fitted to a sigmoidal equation with a mean R (2) of 0.994 +/- 0.003. Intraclass correlation coefficients were all >0.75 (P < 0.001 at all pressure levels). Lower (LIP) and upper inflection (UIP), and deflation maximum curvature (PMC) points calculated from the fitted variables showed a good correlation between methods with intraclass correlation coefficients of 0.98 (0.92, 0.99), 0.92 (0.69, 0.98), and 0.97 (0.86, 0.98), respectively (P < 0.001 in all cases). Bias and limits of agreement for LIP (0.51 +/- 0.95 cmH(2)O; -1.36 to 2.38 cmH(2)O), UIP (0.53 +/- 1.52 cmH(2)O; -2.44 to 3.50 cmH(2)O), and PMC (-0.62 +/- 0.89 cmH(2)O; -2.35 to 1.12 cmH(2)O) obtained with the two methods in the same patient were clinically acceptable. No adverse effects were observed.<bold>Conclusion: </bold>The PV Tool-2 built into the Galileo ventilator is equivalent to the CPAP method for tracing static P-V curves of the respiratory system in critically ill patients receiving mechanical ventilation.
- Publication
Intensive Care Medicine, 2009, Vol 35, Issue 3, p565
- ISSN
0342-4642
- Publication type
journal article
- DOI
10.1007/s00134-008-1322-2