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- Title
Temporal Dynamics of Anti–Type 1 Interferon Autoantibodies in Patients With Coronavirus Disease 2019.
- Authors
Shaw, Elana R; Rosen, Lindsey B; Cheng, Aristine; Dobbs, Kerry; Delmonte, Ottavia M; Ferré, Elise M N; Schmitt, Monica M; Imberti, Luisa; Quaresima, Virginia; Lionakis, Michail S; Notarangelo, Luigi D; Holland, Steven M; Su, Helen C
- Abstract
Binding levels and neutralization activity of anti–type 1 interferon autoantibodies peaked during acute coronavirus disease 2019 and markedly decreased thereafter. Most patients maintained some ability to neutralize type 1 interferon into convalescence despite lower levels of binding immunoglobulin G. Identifying these autoantibodies in healthy individuals before the development of critical viral disease may be challenging.
- Subjects
AUTOANTIBODIES; COMPUTER software; RITUXIMAB; COVID-19; IMMUNOGLOBULINS; CRITICALLY ill; CONVALESCENCE; PATIENTS; INTERFERONS; COMPARATIVE studies; HEMATOPOIETIC stem cell transplantation; LONGITUDINAL method
- Publication
Clinical Infectious Diseases, 2022, Vol 75, Issue 1, pe1192
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciab1002