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- Title
Reduced Influenza B–Specific Postvaccination Antibody Cross-reactivity in the B/Victoria Lineage–Predominant 2019/20 Season.
- Authors
Xie, Hang; Xiang, Ruoxuan; Wan, Hamilton J; Plant, Ewan P; Radvak, Peter; Kosikova, Martina; Li, Xing; Zoueva, Olga; Ye, Zhiping; Wan, Xiu-Feng
- Abstract
Background The influenza activity of the 2019/20 season remained high and widespread in the United States with type B viruses predominating the early season. The majority of B viruses characterized belonged to B/Victoria (B/Vic) lineage and contained a triple deletion of amino acid (aa) 162–164 in hemagglutinin (3DEL). These 3DEL viruses are antigenically distinct from B/Colorado/06/2017 (CO/06)—the B/Vic vaccine component of the 2018/19 and 2019/20 seasons representing the viruses with a double deletion of aa 162–163 in hemagglutinin (2DEL). Methods We performed molecular characterization and phylogenetic analysis of circulating B/Vic viruses. We also conducted hemagglutination inhibition (HAI) assay using archived human postvaccination sera collected from healthy subjects administered with different types of 2018/19 or 2019/20 seasonal vaccines. Their HAI cross-reactivity to representative 3DEL viruses was analyzed. Results The CO/06-specific human postvaccination sera, after being adjusted for vaccine type, had significantly reduced HAI cross-reactivity toward representative 3DEL viruses, especially the 136E+150K subgroup. The geometric mean titers against 3DEL viruses containing 136E+150K mutations were 1.6-fold lower in all populations (P = .051) and 1.9-fold lower in adults (P = .016) compared with those against the 136E+150N viruses. Conclusions Our results indicate that postvaccination antibodies induced by the B/Vic vaccine component of the 2019/20 influenza season had reduced HAI cross-reactivity toward predominant 3DEL viruses in the United States. A close monitoring of the 3DEL 136E+150K subgroup is warranted should this subgroup return and predominate the 2020/21 influenza season.
- Subjects
UNITED States; IMMUNOGLOBULIN analysis; INFLUENZA epidemiology; INFLUENZA vaccines; HEMAGGLUTINATION tests; PHYLOGENY; IMMUNIZATION; DESCRIPTIVE statistics; DRUG allergy
- Publication
Clinical Infectious Diseases, 2021, Vol 72, Issue 11, pe776
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciaa1481