We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Invasive Mycobacterium abscessus Complex Infection After Cardiac Surgery: Epidemiology, Management, and Clinical Outcomes.
- Authors
Baker, Arthur W; Maziarz, Eileen K; Lewis, Sarah S; Stout, Jason E; Anderson, Deverick J; Smith, Peter K; Schroder, Jacob N; Daneshmand, Mani A; Alexander, Barbara D; Wallace, Richard J; Sexton, Daniel J; Wolfe, Cameron R
- Abstract
Background We recently mitigated a clonal outbreak of hospital-acquired Mycobacterium abscessus complex (MABC), which included a large cluster of adult patients who developed invasive infection after exposure to heater-cooler units during cardiac surgery. Recent studies have detailed Mycobacterium chimaera infections acquired during cardiac surgery; however, little is known about the epidemiology and clinical courses of cardiac surgery patients with invasive MABC infection. Methods We retrospectively collected clinical data on all patients who underwent cardiac surgery at our hospital and subsequently had positive cultures for MABC from 2013 through 2016. Patients with ventricular assist devices or heart transplants were excluded. We analyzed patient characteristics, antimicrobial therapy, surgical interventions, and clinical outcomes. Results Ten cardiac surgery patients developed invasive, extrapulmonary infection from M. abscessus subspecies abscessus in an outbreak setting. Median time from presumed inoculation in the operating room to first positive culture was 53 days (interquartile range [IQR], 38–139 days). Disseminated infection was common, and the most frequent culture-positive sites were mediastinum (n = 7) and blood (n = 7). Patients received a median of 24 weeks (IQR, 5–33 weeks) of combination antimicrobial therapy that included multiple intravenous agents. Six patients required antibiotic changes due to adverse events attributed to amikacin, linezolid, or tigecycline. Eight patients underwent surgical management, and 6 patients required multiple sternal debridements. Eight patients died within 2 years of diagnosis, including 4 deaths directly attributable to MABC infection. Conclusions Despite aggressive medical and surgical management, invasive MABC infection after cardiac surgery caused substantial morbidity and mortality. New treatment strategies are needed, and compliance with infection prevention guidelines remains critical.
- Subjects
NORTH Carolina; MYCOBACTERIAL disease treatment; ANTIBIOTICS; MYCOBACTERIUM; CARDIAC surgery; ACADEMIC medical centers; ACQUISITION of data methodology; OPERATIVE surgery; SURGICAL complications; RETROSPECTIVE studies; MEDICAL records; DESCRIPTIVE statistics; MYCOBACTERIAL diseases
- Publication
Clinical Infectious Diseases, 2021, Vol 72, Issue 7, p1232
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciaa215