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- Title
A Systematic Review of Intravaginal Diazepam for the Treatment of Pelvic Floor Hypertonic Disorder.
- Authors
Stone, Rebecca H.; Abousaud, Marin; Abousaud, Aseala; Kobak, William
- Abstract
This systematic review evaluates the efficacy of intravaginal diazepam in treating chronic pelvic pain and sexual dysfunction associated with high‐tone pelvic floor dysfunction. A literature search was conducted in Medline and Web of Science, including articles from the database's inception to July 2019. The search identified 126 articles, and 5 articles met study inclusion criteria: 2 observational reviews and 3 small randomized, controlled trials (RCTs) evaluating intravaginal diazepam for high‐tone pelvic floor dysfunction. The 2 observational studies identified subjective reports of improvement in sexual function for a majority of women, 96% and 71%, in each study. However, there were no statistical differences between Female Sexual Function Index (FSFI) and Visual Analog Scale (VAS) scores for pain identified. One RCT found no significant changes between groups in median FSFI or VAS scores, and a second RCT found no significant changes between groups in 100‐mm VAS scores. The third RCT demonstrated that compared with placebo, treatment with transcutaneous electrical nerve stimulation and intravaginal diazepam for women with vestibulodynia and high‐tone pelvic floor dysfunction yielded significant differences in reduction of dyspareunia (P ≤.05), ability to relax pelvic floor muscles after contraction (P ≤.05), and current perception threshold values at a 5‐Hz stimulation related to C fibers (P <.05), but no significant changes in 10‐cm VAS scores. Intravaginal diazepam may be helpful in women with a specific diagnosis of high‐tone pelvic floor dysfunction, but more and larger studies are needed to confirm these potential effects.
- Subjects
MUSCLE physiology; PELVIC floor physiology; CHRONIC pain; DIAZEPAM; FEMALE reproductive organ diseases; LIFE skills; MEDLINE; MUSCLE contraction; PELVIC pain; TRANSCUTANEOUS electrical nerve stimulation; VAGINAL medication; SYSTEMATIC reviews; SEXUAL dysfunction; TREATMENT effectiveness; PELVIC floor injuries; DESCRIPTIVE statistics; DISEASE complications; EVALUATION
- Publication
Journal of Clinical Pharmacology, 2020, Vol 60, pS110
- ISSN
0091-2700
- Publication type
Article
- DOI
10.1002/jcph.1775