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- Title
Mitochondrial consumption of cytosolic ATP: Not so fast
- Authors
Chinopoulos, Christos
- Abstract
Abstract: In various pathologic circumstances depolarized mitochondria are thought to precipitate cell death by avidly consuming cytosolic ATP. However, for as long as the inner mitochondrial membrane remains intact the reversal potentials of the adenine nucleotide translocase (ANT) and that of F0–F1 ATP synthase are strategically positioned so that they oppose import of cytosolic ATP into the matrix of respiration-impaired mitochondria. This arrangement also seems to protect against a hysteretic consumption of cytosolic ATP accumulating in the mitochondrial matrix, in view of the depolarization caused by inhibition of F0–F1 ATP synthase by the endogenous protein IF1, yielding fast ANT reversal rates.
- Subjects
MITOCHONDRIA; CYTOSOL; CELL death; CELL membranes; ADENINE nucleotides; CHEMICAL synthesis; ENZYMES; PHOSPHORYLATION; CHROMOGENIC compounds
- Publication
FEBS Letters, 2011, Vol 585, Issue 9, p1255
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2011.04.004