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- Title
Patient-reported urinary incontinence following stereotactic body radiation therapy (SBRT) for clinically localized prostate cancer.
- Authors
Chen, Leonard N; Suy, Simeng; Wang, Hongkun; Bhagat, Aditi; Woo, Jennifer A; Moures, Rudy A; Kim, Joy S; Yung, Thomas M; Lei, Siyuan; Collins, Brian T; Kowalczyk, Keith; Dritschilo, Anatoly; Lynch, John H; Collins, Sean P
- Abstract
<bold>Purpose: </bold>Urinary incontinence (UI) following prostate radiotherapy is a rare toxicity that adversely affects a patient's quality of life. This study sought to evaluate the incidence of UI following stereotactic body radiation therapy (SBRT) for prostate cancer.<bold>Methods: </bold>Between February, 2008 and October, 2010, 204 men with clinically localized prostate cancer were treated definitively with SBRT at Georgetown University Hospital. Patients were treated to 35-36.25 Gray (Gy) in 5 fractions delivered with the CyberKnife (Accuray). UI was assessed via the Expanded Prostate Index Composite (EPIC)-26.<bold>Results: </bold>Baseline UI was common with 4.4%, 1.0% and 3.4% of patients reporting leaking > 1 time per day, frequent dribbling and pad usage, respectively. Three year post treatment, 5.7%, 6.4% and 10.8% of patients reported UI based on leaking > 1 time per day, frequent dribbling and pad usage, respectively. Average EPIC UI summary scores showed an acute transient decline at one month post-SBRT then a second a gradual decline over the next three years. The proportion of men feeling that their UI was a moderate to big problem increased from 1% at baseline to 6.4% at three years post-SBRT.<bold>Conclusions: </bold>Prostate SBRT was well tolerated with UI rates comparable to conventionally fractionated radiotherapy and brachytherapy. More than 90% of men who were pad-free prior to treatment remained pad-free three years following treatment. Less than 10% of men felt post-treatment UI was a moderate to big problem at any time point following treatment. Longer term follow-up is needed to confirm late effects.
- Publication
Radiation Oncology, 2014, Vol 9, Issue 1, p148
- ISSN
1748-717X
- Publication type
journal article
- DOI
10.1186/1748-717X-9-148