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- Title
Stability-Indicating HPLC Method for Arteether and Application to Nanoparticles of Arteether.
- Authors
Gugulothu, Dalapathi; Patravale, Vandana
- Abstract
A simple, precise, isocratic, reverse-phase high-performance liquid chromatography method was developed for the rapid determination of arteether using an Agilent RP C18, 4.6 × 150 mm, 5 μm XDB column. The runtime was 9 min. The effect of flow rate, injection volume and mobile phase composition on resolution was investigated. The analytical procedures of the method were validated with respect to precision, accuracy and linearity according to the International Conference on Harmonization guidelines. The limit of detection and the limit of quantitation were 3.3 and 10.0 μg/mL, respectively. Linearity range was from 10.00 to 500 μg/mL. Further, the proposed method was found to be reproducible and convenient for stability-indicating analysis of arteether as a bulk drug and from nanoparticulate formulation.
- Subjects
DRUGS; ANTIMALARIALS; NANOPARTICLES; HIGH performance liquid chromatography; INTERNATIONAL Conference on Harmonisation
- Publication
Journal of Chromatographic Science, 2014, Vol 52, Issue 8, p831
- ISSN
0021-9665
- Publication type
Article
- DOI
10.1093/chromsci/bmt125