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- Title
MCP-1 Production in Temporomandibular Joint Inflammation.
- Authors
Ogura, N.; Satoh, K.; Akutsu, M.; Tobe, M.; Kuyama, K.; Kuboyama, N.; Sakamaki, H.; Kujiraoka, H.; Kondoh, T.
- Abstract
Synovitis, which is characterized by the infiltration of inflammatory cells, often accompanies progression of temporomandibular joint disorder (TMD) symptoms. Because IL-1β is elevated in synovial fluids obtained from TMDs, we hypothesized that IL-1β-responsive genes in synoviocytes may help identify the putative genes associated with synovitis. Using microarray analysis, we found that monocyte chemoattractant protein-1 (MCP-1) mRNA levels were elevated in IL-1β-stimulated synoviocytes. MCP-1 is a member of the chemokine superfamily. The production of MCP-1 was increased in synoviocytes treated with IL-1β. When IL-1β was injected into the cavities of rat TMJs, inflammatory cells and MCP-1-positive cells were detected in the synovial tissues. Furthermore, MCP-1 levels were higher in synovial fluids from individuals with pain compared with those without pain. Inhibitors of MAP-kinases and NF-κB reduced IL-1β-induced MCP-1 production. These results suggest that MCP-1 stimulated by IL-1β is one of the factors associated with the inflammatory progression of TMDs.
- Subjects
INFLAMMATION; TEMPOROMANDIBULAR joint; SYNOVITIS; INTERLEUKIN-1; MESSENGER RNA; PROTEIN microarrays; MONOCYTES; SYNOVIAL membranes; SYNOVIAL fluid; LABORATORY rats
- Publication
Journal of Dental Research, 2010, Vol 89, Issue 10, p1117
- ISSN
0022-0345
- Publication type
Article
- DOI
10.1177/0022034510376041