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- Title
Tongue electrical impedance myography correlates with functional, neurophysiologic, and clinical outcome measures in long‐term oropharyngeal cancer survivors with and without hypoglossal neuropathy: An exploratory study.
- Authors
Hansen, Nathan J.; Woodman, Karin; Buoy, Sheila; Mao, Shitong; Barbon, Carly E. A.; Lai, Stephen Y.; Fuller, C. David; Hutcheson, Katherine A.; Sanchez, Benjamin
- Abstract
Background: This pilot study analyzed correlations between tongue electrical impedance myography (EIM), standard tongue electromyography (EMG), and tongue functional measures in N = 4 long‐term oropharyngeal cancer (OPC) survivors. Methods: Patients were screened for a supportive care trial (NCT04151082). Hypoglossal nerve function was evaluated with genioglossus needle EMG, functional measures with the Iowa oral performance instrument (IOPI), and multi‐frequency tissue composition with tongue EIM. Results: Tongue EIM conductivity was higher for patients with EMG‐confirmed cranial nerve XII neuropathy than those without (p = 0.005) and in patients with mild versus normal EMG reinnervation ratings (16 kHz EIM: p = 0.051). Tongue EIM correlated with IOPI strength measurements (e.g., anterior maximum isometric lingual strength: r2 = 0.62, p = 0.020). Conclusions: Tongue EIM measures related to tongue strength and the presence of XII neuropathy. Noninvasive tongue EIM may be a convenient adjunctive biomarker to assess tongue health in OPC survivors.
- Subjects
ELECTRIC impedance; OROPHARYNGEAL cancer; CANCER survivors; TONGUE; HYPOGLOSSAL nerve
- Publication
Head & Neck, 2024, Vol 46, Issue 3, p581
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.27618