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- Title
Risk factors for carcinoma ex pleomorphic adenoma in patients presenting with recurrence after resection of pleomorphic adenoma.
- Authors
Yin, Linda X.; Van Abel, Kathryn M.; Rooker, Steven A.; Nagelschneider, Alex A.; Olsen, Kerry D.; Price, Daniel L.; Janus, Jeffrey R.; Kasperbauer, Jan L.; Moore, Eric J.
- Abstract
Background: In patients presenting with recurrent pleomorphic adenoma (rPA), clinical evaluation can fail to recognize carcinoma ex PA (cxPA). We aim to identify the risk factors for cxPA. Methods: This is a single institution retrospective case‐control study from 2000 to 2015. CxPA was diagnosed based on surgical pathology. Demographics, clinical, and social histories were collected. Results: A number of 13/106 (12.3%) patients were diagnosed with cxPA, of which only 4/13 (31%) had clinical features suspicious for malignancy. Compared to benign rPA, factors associated with cxPA included age >50 (odds ratio [OR] 6.67, 95% confidence interval [CI]: 1.71‐25.98, P <.01), >10 pack‐years of smoking history (OR 3.36, 95% CI: 1.01‐11.14, P =.04), and the largest tumor being >2 cm on pathology (OR 4.42, 95% CI: 1.14‐17.10, P =.03). Conclusions: In patients presenting with rPA, risk factors for malignant transformation include age >50, significant smoking history, and tumors larger than 2 cm. Clinical signs of malignancy such as rapid growth or pain are not always present.
- Subjects
DISEASE relapse; SYMPTOMS; CARCINOMA; SURGICAL pathology; SALIVARY gland cancer; PAROTID gland tumors
- Publication
Head & Neck, 2021, Vol 43, Issue 2, p419
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.26489