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- Title
Morphologic and topographic radiologic features of human papillomavirus-related and -unrelated oropharyngeal carcinoma.
- Authors
Chan, Michael W.; Yu, Eugene; Bartlett, Eric; O'Sullivan, Brian; Su, Jie; Waldron, John; Ringash, Jolie; Bratman, Scott V.; Chen, Yingming Amy; Irish, Jonathan; Kim, John; Gullane, Patrick; Gilbert, Ralph; Chepeha, Douglas; Perez‐Ordonez, Bayardo; Weinreb, Ilan; Hansen, Aaron; Tong, Li; Xu, Wei; Huang, Shao Hui
- Abstract
Background The purpose of this study was to compare the clinicoradiologic characteristics of human papillomavirus (HPV)-related (HPV-positive) and HPV-unrelated (HPV-negative) oropharyngeal carcinoma (OPC). Methods Primary tumor and lymph node features of HPV-positive and HPV-negative OPCs from 2008 to 2013 were compared on pretreatment CT/MRI. Intrarater/interrater concordance was assessed. Multivariable analyses identified factors associated with HPV-positivity to be used in nomogram construction. Results Compared to HPV-negative (n = 194), HPV-positive (n = 488) tumors were more exophytic (73% vs 63%; p = .02) with well-defined border (58% vs 47%; p = .033) and smaller axial dimensions; lymph node involvement predominated (89% vs 69%; p < .001) with cystic appearance (45% vs 32%; p = .009) but similar topography. Intrarater/interrater concordance varied (fair to excellent). Nomograms combining clinical (age, sex, smoking pack-years, subsite, T/N classification) and/or radiologic (nonnecrotic tumor and cystic lymph node) features were used to weigh the likelihood of HPV-driven tumors (area under the curve [AUC] = 0.84). Conclusion HPV-positive OPC has different radiologic tumor (exophytic/well-defined border/smaller axial dimension) and lymph node (cystic) features but similar lymph node topography.
- Subjects
PAPILLOMAVIRUSES; CANCER treatment; OROPHARYNGEAL cancer; COMPUTED tomography; MAGNETIC resonance imaging
- Publication
Head & Neck, 2017, Vol 39, Issue 8, p1524
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.24764