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- Title
Bone Formation During Distraction Osteogenesis Is Dependent on Both VEGFR1 and VEGFR2 Signaling.
- Authors
Jacobsen, Kimberly A.; Al-Aql, Zainab S.; Chao Wan; Fitch, Jennifer L.; Stapleton, Stephanie N.; Mason, Zachary D.; Cole, Robert M.; Gilbert, Shawn R.; Clemens, Thomas L.; Morgan, Elise F.; Einhorn, Thomas A.; Gerstenfeld, Louis C.
- Abstract
The article presents a study which evaluates whether bone formation during distraction osteogenesis (DO) is strictly dependent on vascularization. To determine its association, researchers have inhibited vascular endothelial growth factor (VEGF) activity by antibody blockade of both receptors VEGFR1 and VEGFR2, or only VEGFR2 in a previously developed murine tibia DO model. Results reveal that both VEGFR1 and VEGFR2 are functionally essential in blood vessel and bone formation during DO.
- Subjects
BONE growth; VASCULAR endothelial growth factors; GROWTH factors; IMMUNOGLOBULINS; BLOOD-vessel development; BONE morphogenetic proteins
- Publication
Journal of Bone & Mineral Research, 2008, Vol 23, Issue 5, p596
- ISSN
0884-0431
- Publication type
Article
- DOI
10.1359/JBMR.080103