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- Title
Severe Acute Respiratory Syndrome Coronavirus 2-Induced Immune Activation and Death of Monocyte-Derived Human Macrophages and Dendritic Cells.
- Authors
Zheng, Jian; Wang, Yuhang; Li, Kun; Meyerholz, David K; Allamargot, Chantal; Perlman, Stanley
- Abstract
Studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients and experimentally infected animals indicate a critical role for augmented expression of proinflammatory chemokines and cytokines in severe disease. Here, we demonstrate that SARS-CoV-2 infection of human monocyte-derived macrophages (MDMs) and monocyte-derived dendritic cells was abortive, but induced the production of multiple antiviral and proinflammatory cytokines (interferon-α, interferon-β, tumor necrosis factor, and interleukins 1β, 6, and 10) and a chemokine (CXCL10). Despite the lack of efficient replication in MDMs, SARS-CoV-2 induced profound interferon-mediated cell death of host cells. Macrophage activation and death were not enhanced by exposure to low levels of convalescent plasma, suggesting that antibody-dependent enhancement of infection does not contribute to cell death. Together, these results indicate that infection of macrophages and dendritic cells potentially plays a major role in coronavirus disease 2019 pathogenesis, even in the absence of productive infection.
- Subjects
COVID-19; DENDRITIC cells; TUMOR necrosis factors; CONVALESCENT plasma
- Publication
Journal of Infectious Diseases, 2021, Vol 223, Issue 5, p785
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiaa753