We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Tumor Necrosis Factor-Superfamily 15 Gene Expression in Patients with Sickle Cell Disease.
- Authors
Özçimen, Ahmet Ata; Ünal, Selma; Canacankatan, Necmiye; Antmen, Şerife Efsun
- Abstract
Objective: The aim of this study was to investigate the relation between tumor necrosis factor-superfamily 15 (TNFSF15) gene expression and clinical findings in children with sickle cell disease (SCD). Materials and Methods: Forty-nine patients with SCD and 38 healthy controls were included in this study. TNFSF15 gene expression and plasma levels were analyzed. TNFSF15 gene expression was compared in subgroups considering the frequency of painful crises and acute chest syndrome (ACS). Results: It was found that TNFSF15 gene expression was significantly higher in patients with SCD than the controls (p=0.001), whereas there was no significant difference between the patients with SCD and the control groups considering plasma levels of TNFSF15. TNFSF15 gene expression was also significantly higher in SCD patients with ACS (p=0.008). Conclusion: These findings suggest that TNFSF15 may have a role in the pathogenesis of SCD presenting with ACS. Further studies on larger groups are needed to determine the function of TNFSF15 in SCD patients with ACS and pulmonary hypertension. Analysis of TNFSF15 expression may also serve as a promising approach in ACS therapy.
- Subjects
TURKEY; BLOOD serum analysis; ACADEMIC medical centers; CHILDREN'S hospitals; ENZYME-linked immunosorbent assay; GENE expression; POLYMERASE chain reaction; PROBABILITY theory; RESEARCH; SICKLE cell anemia; STATISTICS; TUMOR necrosis factors; MATHEMATICAL variables; DATA analysis; DATA analysis software; DESCRIPTIVE statistics; MANN Whitney U Test; KRUSKAL-Wallis Test
- Publication
Turkish Journal of Hematology, 2014, Vol 31, Issue 3, p255
- ISSN
1300-7777
- Publication type
Article
- DOI
10.4274/tjh.2012.0130