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- Title
Use of BARD scoring system in non-alcoholic fatty liver disease patients and its correlation with ultrasonographic grading in Gizan, Saudi Arabia.
- Authors
Ageely, Hussein M.; Elmakki, Erwa M.; Bani, Ibrahim A.; Mohamed, Husam O.; Taher, Asim A.; Hadi, Talal O.; Abdalla, Saif Elden B.; Hendi, Ali M.; Mahfouz, Mohamed Salih
- Abstract
Purpose: To assess the efficacy of the BARD scoring system in Saudi non-alcoholic fatty liver disease (NAFLD) patients attending Gizan General Hospital and to identify the clinical variables associated with advanced fibrosis. . Methods: The cross-sectional study involved 120 patients aged ≥ 18 years who attended the Ultrasound Department of Gizan General Hospital, Gizan, Saudi Arabia, during January - June 2013. BARD scoring system comprised the following variables: body mass index (BMI) ≥ 28 = 1 point, aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio ≥ 0.8 = 2 points, and type 2 diabetes mellitus = 1 point. Results: Patients with advanced fibrosis were older (55.0 years) than patients with no/mild fibrosis (48.6 years), albeit not significantly so. A higher BMI was associated with advanced fibrosis in males, females and all study participants (p = 0.013, 0.016 and 0.001, respectively). Advanced fibrosis was more common in older patients with a higher weight to height ratio. Logistic regression suggested that age ≥ 50 years was associated with a 2.52-fold increase in the risk of advanced fibrosis, but this did not have a significant clinical impact (p = 0.087). BMI > 28 was associated with a 26.73-fold increased risk of advanced fibrosis, while AST/ALT ≥ 0.8 was associated with an 18.46-fold increased risk of advanced liver fibrosis (p = 0.002 and 0.006, respectively). Conclusion: The major risk factors for advanced fibrosis using BARD scoring system in patients with NAFLD were old age, BMI > 28, and AST/ALT ≥ 0.8. In addition, grade 3 ultrasonographic fatty liver significantly correlated with advanced fibrosis.
- Subjects
FATTY liver; FIBROSIS; BODY mass index; ASPARTATE aminotransferase; ALANINE aminotransferase; TYPE 2 diabetes; ULTRASONIC imaging
- Publication
Tropical Journal of Pharmaceutical Research, 2016, Vol 15, Issue 4, p841
- ISSN
1596-5996
- Publication type
Article
- DOI
10.4314/tjpr.v15i4.25