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- Title
In vitro SYNERGISM OF SIMVASTATIN AND FLUCONAZOLE AGAINST Candida SPECIES.
- Authors
Menezes, Everardo Albuquerque; Vasconcelos Júnior, Antônio Alexandre De; Façanha Silva, Carlla Lorena; Plutarco, Fábio Ximenes; Santos Oliveira Cunha, Maria Da Conceição Dos; Cunha, Francisco Afrânio
- Abstract
Systemic fungal infections are responsible for high mortality rates. Several species of fungi may be involved, but Candida spp. is the most prevalent. Simvastatin is used to lower cholesterol and also exhibits antifungal action. The aim of this study was to evaluate the synergistic action of simvastatin with fluconazole against strains of Candida spp. Susceptibility testing was performed according to protocol M27-A3, by broth microdilution method and the synergistic effect of simvastatin and fluconazole was calculated based on FICI (Fractional Inhibitory Concentration Index). Eleven strains were evaluated, and simvastatin showed a synergistic effect with fluconazole against 10 (91%) of the Candida spp. strains tested. Simvastatin may be a valuable drug in the treatment of systemic infections caused by Candida spp.
- Subjects
CANDIDIASIS treatment; DRUG synergism; SIMVASTATIN; FLUCONAZOLE; MORTALITY; ANTIFUNGAL agents; COMMUNICABLE disease treatment; MYCOSES
- Publication
Revista do Instituto de Medicina Tropical de São Paulo, 2012, Vol 54, Issue 4, p197
- ISSN
0036-4665
- Publication type
Article
- DOI
10.1590/S0036-46652012000400003