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- Title
Yiqihuoxue Formula Activates Autophagy and Offers Renoprotection in a Rat Model of Adenine-Induced Kidney Disease.
- Authors
Xia, Chen Hui; Han, Xue Ting; Zhang, Xueqin; Zhu, Ze Bing; Guo, Jing; Cui, Hai Lan; Jiang, Han Xue; Huang, Wei Jun; Chen, Guo Zi; Liu, Yu Ning; Liu, Wei Jing
- Abstract
Chronic kidney disease (CKD) is a worldwide health problem for which effective therapeutic methods are still lacking. Traditional Chinese medicine (TCM) has been indicated as an effective alternative treatment for kidney disease. In this study, a clinically effective therapy, yiqihuoxue (YQHX) formula, was administrated to adenine-induced kidney disease rats for 6 weeks. We found that the adenine rats displayed a significant reduction in renal function as evidenced by the increased levels of serum creatinine (Scr), blood urea nitrogen (BUN), and 24-h urinary albumin level, which were attenuated by the YQHX treatment. The glomerulosclerosis, interstitial fibrosis, arteriolosclerosis, interstitial inflammation, and tubular dilatation were reversed by the YQHX treatment in the adenine rats. Furthermore, the hepatic damage characterized by increased levels of aspartate aminotransferase and alanine aminotransferase and inflammatory cell infiltration was improved by YQHX. In addition, the number of apoptotic cells in the adenine rats was obviously reduced by the YQHX treatment as manifested by the lower expression level of cleaved caspase-3 protein. Moreover, the YQHX treatment downregulated the expression levels of fibronectin, type I collagen, α-smooth muscle actin, and TGF-β1 in the adenine rats. Furthermore, autophagy was activated by the YQHX treatment, which manifested as an increased LC3-II and Beclin-1 expression levels and a decreased p62 level. In conclusion, the YQHX formula might retard the progression of kidney disease by activating autophagy.
- Subjects
ARTERIOSCLEROSIS prevention; INFLAMMATION prevention; AUTOPHAGY; ANIMAL experimentation; APOPTOSIS; ASPARTATE aminotransferase; CHRONIC kidney failure; COLLAGEN; CREATININE; FIBRONECTINS; GENE expression; GLOMERULONEPHRITIS; HERBAL medicine; INTERSTITIAL lung diseases; KIDNEYS; LUNGS; CHINESE medicine; MUSCLE proteins; PROTEINS; RATS; TIME; TRANSFORMING growth factors-beta; VITAMIN B complex; ALBUMINS; ALANINE aminotransferase; NUCLEAR proteins; CASPASES; BLOOD urea nitrogen; DRUG administration; DRUG dosage
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2019, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2019/3423981