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- Title
Multiple breath washout testing in adults with pulmonary disease and healthy controls - can fewer measurements eventually be more?
- Authors
Trinkmann, Frederik; Götzmann, Johannes; Saur, Daniel; Schroeter, Michele; Roth, Katharina; Stach, Ksenija; Borggrefe, Martin; Saur, Joachim; Akin, Ibrahim; Michels, Julia D.
- Abstract
<bold>Background: </bold>Multiple breath washout (MBW) became a valuable research tool assessing ventilation heterogeneity. However, routine clinical application still faces several challenges. Deriving MBW parameters from three technically acceptable measurements according to current recommendations prolongs test times. We therefore aimed to evaluate reporting only duplicate measurements in healthy adults and pulmonary disease.<bold>Methods: </bold>One hundred and fifty-three subjects prospectively underwent conventional lung function testing and closed-circuit SF6-MBW. Three technically acceptable MBW-measurements were obtained in 103 subjects.<bold>Results: </bold>Lung clearance index (LCI) differed significantly among 19 controls (7.4 ± 0.8), 19 patients with sarcoidosis (8.1 ± 1.2), 32 with bronchial asthma (9.2 ± 1.9) and 33 with COPD (10.8 ± 2.2, p < 0.001). Within-test repeatability was high (coefficient of variation between 2.5% in controls and 3.6% in COPD) and remained unchanged when only including the first two measurements. Likewise, LCI remained stable with mean absolute changes ranging from 0.9 ± 0.8% in controls to 1.5 ± 0.9% in COPD (p = 0.1). Mean test time reduction differed significantly between groups reaching 200 s in COPD (p = 0.01).<bold>Conclusions: </bold>Duplicate SF6-MBW-measurements are sufficient in adult patients with pulmonary disease and healthy controls. LCI values and intra-test repeatability are not affected reducing total test time statistically significant. Our findings have the potential to further facilitate application of MBW in research and clinical routine.<bold>Trial Registration: </bold>NCT03176745 , June 2, 2017 retrospectively registered.
- Subjects
BREATH tests; LUNG disease diagnosis; PULMONARY function tests; ASTHMA; SARCOIDOSIS; ASTHMA diagnosis; OBSTRUCTIVE lung disease diagnosis; SARCOIDOSIS diagnosis; CLINICAL trials; LUNGS; RESEARCH evaluation
- Publication
BMC Pulmonary Medicine, 2017, Vol 17, p1
- ISSN
1471-2466
- Publication type
journal article
- DOI
10.1186/s12890-017-0543-y