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- Title
Association of serum oleic acid level with depression in American adults: a cross-sectional study.
- Authors
Yin, Jiahui; Li, Siyuan; Li, Jinling; Gong, Rongpeng; Jia, Zhixia; Liu, Junjun; Jin, Zhi; Yang, Jiguo; Liu, Yuanxiang
- Abstract
Background: As the most abundant fatty acid in plasma, oleic acid has been found to be associated with multiple neurological diseases; however, results from studies of the relationship between oleic acid and depression are inconsistent. Methods: This cross-sectional study analyzed 4,459 adults from the National Health and Nutrition Examination Survey 2011–2014. The following covariates were adjusted in multivariable logistic regression models: age, sex, race/ethnicity, education level, marital status, body mass index, physical activity, smoking status, alcohol status, metabolic syndrome, omega-3 polyunsaturated fatty acids, and total cholesterol. Results: Serum oleic acid levels were positively associated with depression. After adjusting for all covariates, for every 1 mmol/L increase in oleic acid levels, the prevalence of depression increased by 40% (unadjusted OR: 1.35, 95%CI: 1.16–1.57; adjusted OR: 1.40, 95% CI: 1.03–1.90). Conclusions: Our study suggests that oleic acid may play a role in depression. Further research is needed to investigate the potential benefits of changing oleic acid levels for the treatment and prevention of depression.
- Subjects
OLEIC acid; HEALTH &; Nutrition Examination Survey; UNSATURATED fatty acids; OMEGA-3 fatty acids; CROSS-sectional method
- Publication
BMC Psychiatry, 2023, Vol 23, Issue 1, p1
- ISSN
1471-244X
- Publication type
Article
- DOI
10.1186/s12888-023-05271-0