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- Title
Stimulation of Midgut Stem Cell Proliferation and Differentiation by Insect Hormones and Peptides.
- Authors
SMAGGHE, GUY; VANHASSEL, WENDY; MOEREMANS, CLARINA; WILDE, DAAN; GOTO, SHINTARO; LOEB, MARCIA J.; BLACKBURN, MICHAEL B.; HAKIM, RAZIEL S.
- Abstract
Stem cells derived from midguts of the caterpillar, Spodoptera littoralis, can be induced to multiply and differentiate in vitro. Ecdysone (E) and 20-hydroxyecdysone (20E) had a concentration-dependent effect: E was more active in cell proliferation and 20E in differentiation. Ecdysteroid receptors in midgut stem cell nuclei were stained with the antibody 9B9. In addition, α-arylphorin and four midgut differentiation factors (MDF) specifically stimulated proliferation and differentiation of stem cells, respectively. The activity of a panel of peptide growth factors and hormones on growth and metamorphosis of the insect midgut is discussed.
- Subjects
STEM cells; CATERPILLARS; INSECT hormones; SPODOPTERA littoralis; PEPTIDES; FERTILIZATION in vitro
- Publication
Annals of the New York Academy of Sciences, 2005, Vol 1040, Issue 1, p472
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1196/annals.1327.094