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- Title
Sex Hormones in Women With Elevated Breast Cancer Risk Undergoing Weight Loss.
- Authors
Stone, Sophia A.; Han, Claire J.; Senn, Taurence; Korde, Larissa A.; Allott, Kristen; Reding, Scott; Whittington, Dale; Reding, Kerryn W.
- Abstract
Sedentary lifestyles and obesity are known risk factors for breast cancer. Elevated estrogen levels correlate with obesity and, independently, with increased breast cancer risk. Lifestyle interventions that reduce obesity may mitigate this risk, potentially via estrogen pathways. In a 6-month lifestyle intervention, overweight/obese women with high breast cancer risk were randomized to control (n = 7) or intervention (n = 6) and analyzed for sex hormone levels. Serum and urine hormones were evaluated by ultra performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS) and sex hormone binding globulin (SHBG) by enzyme-linked immunosorbent assay (ELISA). Serum estrone (E1) and estradiol (E2) were reduced by 12.1% and 50.8%, respectively, at 9 months in the intervention group, which differed from controls (p =.043 and.020). This contrasted with a 73.3% increase in urine E1 at 6 months in the intervention group (p =.035). These results suggest that a lifestyle intervention led to a favorable estrogen profile in relation to breast cancer risk.
- Subjects
BREAST tumor risk factors; BEHAVIOR modification; ENZYME-linked immunosorbent assay; ESTRADIOL; ESTROGEN; FISHER exact test; GLOBULINS; HEALTH behavior; SEX hormones; LIQUID chromatography; MASS spectrometry; GENETIC mutation; HEALTH outcome assessment; QUESTIONNAIRES; RESEARCH funding; RISK assessment; STATISTICAL sampling; STATISTICS; WEIGHT loss; WOMEN'S health; SAMPLE size (Statistics); PILOT projects; DATA analysis; BODY mass index; RANDOMIZED controlled trials; PRE-tests &; post-tests; HUMAN research subjects; PATIENT selection; DATA analysis software; MINDFULNESS; DESCRIPTIVE statistics; KRUSKAL-Wallis Test
- Publication
Western Journal of Nursing Research, 2019, Vol 41, Issue 11, p1602
- ISSN
0193-9459
- Publication type
Article
- DOI
10.1177/0193945918820672