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- Title
Effects on Liver Hydrogen Peroxide Metabolism Induced by Dietary Selenium Deficiency or Excess in Chickens.
- Authors
Xu, Jing-Xiu; Cao, Chang-Yu; Sun, Yan-Chun; Wang, Li-Li; Li, Nan; Xu, Shi-Wen; Li, Jin-Long
- Abstract
To determine the relationship between dietary selenium (Se) deficiency or excess and liver hydrogen peroxide (HO) metabolism in chickens, 1-day-old chickens received insufficient Se (0.028 mg Se per kg of diet) or excess Se (3.0 or 5.0 mg Se per kg of diet) in their diets for 8 weeks. Body and liver weight changes, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, HO content, and activities and mRNA levels of enzymes associated with HO metabolism (catalase (CAT) and superoxide dismutase (SOD) 1-3) were determined in the liver. This study showed that Se deficiency or excess Se intake elicited relative severe changes. Se deficiency decreased growth, while Se excess promoted growth in chickens. Both diets vastly altered the liver function, but no obvious histopathological changes were observed in the liver. Se deficiency significantly lowered SOD and CAT activities, and the HO content in the liver and serum increased. Se excess (3.0 mg/kg) decreased SOD and CAT activities with changes in their mRNA levels, and the HO content increased. The larger Se excess (5.0 mg/kg) showed more serious effects but was not fatal. These results indicated that the HO metabolism played a destructive role in the changes in bird liver function induced by Se deficiency or excess.
- Subjects
PHYSIOLOGICAL effects of hydrogen peroxide; SELENIUM in animal nutrition; METABOLISM; POULTRY research; PHYSIOLOGICAL effects of trace elements
- Publication
Biological Trace Element Research, 2014, Vol 159, Issue 1-3, p174
- ISSN
0163-4984
- Publication type
Article
- DOI
10.1007/s12011-014-0002-z