We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Development and Validation of a Risk Scoring Model to Predict Net Adverse Cardiovascular Outcomes after Primary Percutaneous Coronary Intervention in Patients Pretreated with 600 mg Clopidogrel: Rationale and Design of the RISK-PCI Study.
- Authors
Mrddovic, Igor; Savic, Lidija; Perunicic, Jovan; Asanin, Milika; Lasica, Ratko; Marinkovic, Jelena; Vasiljevic, Zorana; Ostojic, Miodrag
- Abstract
Background: No comprehensive primary PCI (pPCI) risk model to predict net adverse cardiovascular events (NACE) has been reported with the use of clopidogrel 600 mg, which is now considered the standard loading dose. The primary hypothesis of the RISK-PCI trial is that an accurate risk prediction may be achieved by using clinical, angiographic, and procedural variables available at the time of intervention. Methods: The present single-center, longitudinal, cohort study will include 1,750 consecutive patients with ST-elevation myocardial infarction (STEMI), undergoing pPCI after pretreatment with 300 mg aspirin and 600 mg clopidogrel. The primary end-points of the trial (NACE) include major adverse cardiovascular events (MACE) and major bleeding. A logistic regression model will be developed to predict 30-day and 1-year NACE after pPCI. A risk score derived from study set data will be validated using validation set data. Results: Until June 1, 2008, 1,166 patients have been enrolled. Thirty-day follow-up is available in 1,007 patients. Conclusions: The RISK-PCI study is designed to develop an accurate risk scoring system, using variables available at the time of intervention, to predict long-term adverse outcomes after pPCI. Trial Registration: Current Controlled Trials Register—ISRCTN83474650— .
- Subjects
DRUG side effects; CARDIOVASCULAR diseases; MYOCARDIAL infarction; ASPIRIN; HEMORRHAGE; LOGISTIC regression analysis; HEALTH outcome assessment; PATIENTS
- Publication
Journal of Interventional Cardiology, 2009, Vol 22, Issue 4, p320
- ISSN
0896-4327
- Publication type
Article
- DOI
10.1111/j.1540-8183.2009.00476.x