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- Title
Antitumor activity of biflavonoids from Ouratea and Luxemburgia on human cancer cell lines.
- Authors
de Souza Daniel, Juliana Feijó; Alves, Cassia Cristina Fernandes; Grivicich, Ivana; da Rocha, Adriana Brondani; de Carvalho, Mário Geraldo
- Abstract
The biflavones 7,7″dimethyllanaraflavone (1), agathisflavone (2), and 7″-methylagathisflavone (3) isolated from the leaves of Ouratea hexasperma and luxenchalcone (4) isolated from the leaves and branches of Luxemburgia octandra, as well as a mixture of 7,7″-dimethyllanaraflavone and 7″-methylagathisflavone, were assayed against HT-29 colon adenocarcinoma, NCl-H460 non-small cell lung carcinoma, MCF-7 breast cancer cell, OVCAR-3 ovarian adenocarcinoma cells, and RXF-393 renal cell carcinoma. The results show significant activities, particularly for 7,7″-dimethyllanaraflavone (IC50 0.77±0.08, 2.42±0.22, and 2.59±0.32 μg/ml for NCl-H460, MCF-7, and OVCAR-3, respectively), and for 7″-methylagathisflavone (IC50 values of 4 μg/ml). Luxenchalcone revealed significant cytotoxicity on the five cell lines tested.
- Subjects
ANTINEOPLASTIC agents; CANCER cells; OURATEA; ADENOCARCINOMA; CELL-mediated cytotoxicity; MEDICAL research
- Publication
Indian Journal of Pharmacology, 2007, Vol 39, Issue 4, p184
- ISSN
0253-7613
- Publication type
Article