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- Title
Current Understanding of the Anatomy, Physiology, and Magnetic Resonance Imaging of Neurofluids: Update From the 2022 "ISMRM Imaging Neurofluids Study group" Workshop in Rome.
- Authors
Agarwal, Nivedita; Lewis, Laura D.; Hirschler, Lydiane; Rivera, Leonardo Rivera; Naganawa, Shinji; Levendovszky, Swati Rane; Ringstad, Geir; Klarica, Marijan; Wardlaw, Joanna; Iadecola, Costantino; Hawkes, Cheryl; Carare, Roxana Octavia; Wells, Jack; Bakker, Erik N.T.P.; Kurtcuoglu, Vartan; Bilston, Lynne; Nedergaard, Maiken; Mori, Yuki; Stoodley, Marcus; Alperin, Noam
- Abstract
This article, titled "Current Understanding of the Anatomy, Physiology, and Magnetic Resonance Imaging of Neurofluids: Update From the 2022 'ISMRM Imaging Neurofluids Study group' Workshop in Rome," discusses the use of intrathecal enhanced MRI (GMRI) to study the brain's clearance rate of molecules larger than water. The study found that clearance from cerebrospinal fluid (CSF) is a limiting step for brain clearance, and that CSF tracer enrichment in brain tissue varies across different regions of the brain. The article also notes that CSF-ISF exchange may not play a major role in brain molecular clearance from deep structures. The findings have implications for the delivery of therapeutic drugs intrathecally.
- Subjects
ROME; MAGNETIC resonance imaging; DIAGNOSTIC imaging; ANATOMY; PHYSIOLOGY; MOLECULAR size
- Publication
Journal of Magnetic Resonance Imaging, 2024, Vol 59, Issue 2, pspcone
- ISSN
1053-1807
- Publication type
Article
- DOI
10.1002/jmri.28759