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- Title
Application of Multiparametric Magnetic Resonance Imaging to Monitor the Early Antitumor Effect of CuS@GOD Nanoparticles in a 4 T1 Breast Cancer Xenograft Model.
- Authors
Ye, Yao‐Jiang; Huang, Xiu‐Jie; Luo, Bi‐Chong; Wang, Xiao‐Ying; Cai, Xiang‐Ran
- Abstract
Background: We have developed hybrid nanoparticles (NPs) by co‐loading copper sulfide (CuS) NPs and glucose oxidase (GOD) (CuS@GOD NPs) to explore their antitumor properties. Purpose To investigate the feasibility of using multiparametric magnetic resonance imaging (MRI) including intravoxel incoherent motion diffusion‐weighted imaging (IVIM‐DWI) and R2* mapping to quantitatively assess the early antitumor effect of CuS@GOD NPs. Study type: Prospective. Animal model: The orthotopic BALB/c mice 4 T1 breast cancer model. The 4 T1 xenografts in group 1 mice received normal saline, group 2 received CuS@GOD NPs, group 3 received CuS NPs plus laser, and group 4 received CuS@GOD NPs plus laser (n = 28 for each group). Field Strength/Sequence: A 3.0 T/IVIM‐DWI MRI single‐shot echo‐planar imaging, R2* mapping spoiled gradient recalled echo (SPGR) sequence, T2‐weighted images (T2WI) and T1‐weighted images (T1WI) fast spin echo (FSE) sequence. Assessment The IVIM‐DWI and R2* mapping were performed before and after treatment at 0 hour, 0.5 hour, 1 hour, 2 hours, 4 hours, and 24 hours in four groups and the MRI parameters were obtained. Correlation analysis between the MRI parameters and histological analyses was conducted. Statistical Tests: One‐way ANOVA, Pearson's correlation analysis, two independent samples t test, intraclass correlation coefficient. P < 0.05 was considered to be statistically significant. Results: In group 4, the tumoral D value was significantly higher than that of group 2 at 24 hours (0.541 ± 0.065 vs. 0.492 ± 0.051). The f value of group 4 was significantly lower than that of groups 1 and 2 at 2 hours (10.83 ± 2.16 vs. 14.28 ± 1.86, 16.67 ± 3.53, respectively). The R2* value was significantly increased at 0 hour in group 4 compared to that of groups 1 and 2 (64.552 ± 4.663 vs. 42.441 ± 1.516, 43.165 ± 1.709, respectively). D, f, and R2* were correlated with the histological staining results (r = 0.695–0.970). Data Conclusion: The IVIM‐DWI‐derived D and f and R2* mapping‐derived R2* could monitor early response to CuS@GOD NPs treatment in vivo. Evidence Level 2 Technical Efficacy: Stage 2
- Subjects
MAGNETIC resonance imaging; MAGNETICS; ECHO-planar imaging; DIFFUSION magnetic resonance imaging; BREAST cancer
- Publication
Journal of Magnetic Resonance Imaging, 2022, Vol 55, Issue 1, p301
- ISSN
1053-1807
- Publication type
Article
- DOI
10.1002/jmri.27867