We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Acute kidney damage induced by low- and iso-osmolar contrast media in rats: Comparison study with physiologic MRI and histologic-gene examination.
- Authors
Wu, Chen‐Jiang; Bao, Mei‐Ling; Wang, Qing; Wang, Xiao‐Ning; Liu, Xi‐Sheng; Shi, Hai‐Bin; Zhang, Yu‐Dong; Wu, Chen-Jiang; Bao, Mei-Ling; Wang, Xiao-Ning; Liu, Xi-Sheng; Shi, Hai-Bin; Zhang, Yu-Dong
- Abstract
<bold>Purpose: </bold>To investigate the physiopathological effects of low- and iso-osmolar contrast media (CM) on renal function with physiologic MRI and histologic-gene examination.<bold>Materials and Methods: </bold>Forty-eight rats underwent time-course DWI and DCE-MRI at 3.0 Tesla (T) before and 5-15 min after exposure of CM or saline (Iop.370: 370 mgI/mL iopromide; Iod.320: 320 mgI/mL iodixanol; Iod.270: 270 mgI/mL iodixanol; 4 gI/kg body weight). Intrarenal viscosity was reflected by apparent diffusion coefficient (ADC). Renal physiologies were evaluated by DCE-derived glomerular filtration rate (GFR), renal blood flow (RBF), and renal blood volume (RBV). Potential acute kidney injury (AKI) was determined by histology and the expression of kidney injury molecule 1 (Kim-1).<bold>Results: </bold>Iop.370 mainly increased ADC in inner-medulla (△ADCIM : 12.3 ± 11.1%; P < 0.001). Iod.320 and Iod.270 mainly decreased ADC in outer-medulla (△ADCIM ; Iod.320: 16.8 ± 7.5%; Iod.270: 18.1 ± 9.5%; P < 0.001) and inner-medulla (△ADCIM ; Iod.320: 28.4 ± 9.3%; Iod.270: 30.3 ± 6.3%; P < 0.001). GFR, RBF and RBV were significantly decreased by Iod.320 (△GFR: 45.5 ± 24.1%; △RBF: 44.6 ± 19.0%; △RBV: 35.2 ± 10.1%; P < 0.001) and Iod.270 (33.2 ± 19.0%; 38.1 ± 15.6%; 30.1 ± 10.1%; P < 0.001), while rarely changed by Iop.370 and saline. Formation of vacuoles and increase in Kim-1 expression was prominently detected in group of Iod.320, while rarely in Iod.270 and Iop.370.<bold>Conclusion: </bold>Iso-osmolar iodixanol, given at high-dose, produced prominent AKI in nonhydrated rats. This renal dysfunction could be assessed noninvasively by physiologic MRI.<bold>Level Of Evidence: </bold>1 J. Magn. Reson. Imaging 2017;45:291-302.
- Subjects
ACUTE kidney failure; ANIMAL experimentation; DOSE-effect relationship in pharmacology; GROWTH factors; MAGNETIC resonance imaging; RATS; CONTRAST media; OSMOLAR concentration; DRUG administration; DRUG dosage
- Publication
Journal of Magnetic Resonance Imaging, 2017, Vol 45, Issue 1, p291
- ISSN
1053-1807
- Publication type
journal article
- DOI
10.1002/jmri.25346