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- Title
Tumor necrosis factor alpha −308 polymorphism is associated with rheumatoid arthritis in Han population of Eastern China.
- Authors
Ruiwen Chen; Meng Fang; Qing Cai; Shiwei Duan; Ke Lv; Ning Cheng; Daming Ren; Jie Shen; Dongyi He; Lin He; Shuhan Sun
- Abstract
The aim of this study was to investigate the association of single nucleotide polymorphisms (SNPs) in tumor necrosis factor alpha ( TNFα) promoter with rheumatoid arthritis (RA) in Chinese Han population. Six SNPs at positions −238, −244, −308, −376, −857, −863 within TNFα promoter were genotyped in 367 unrelated RA patients and 271 healthy controls, using direct DNA sequencing method. Allelic, genotypic, and haplotypic associations of these SNPs with RA were examined. The frequencies of TNFα −308A allele and the haplotype GACC (in order of −238, −308, −857, −863) were significantly lower in RA patients when compared with healthy controls ( P = 0.0046, P = 0.0045, respectively) but TNFα −308 polymorphism was not related to the clinical manifestations of RA patients. These results implied that TNFα gene itself or a gene in linkage disequilibrium with it might be associated with RA in Han population of Eastern China.
- Subjects
CHINA; TUMOR necrosis factors; GENETIC polymorphisms; PROMOTERS (Genetics); AUTOIMMUNE diseases; RHEUMATOID arthritis; NUCLEOTIDE sequence
- Publication
Rheumatology International, 2007, Vol 28, Issue 2, p121
- ISSN
0172-8172
- Publication type
Article
- DOI
10.1007/s00296-007-0409-3