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- Title
Breath-holding time: effects of non-chemical factors in divers and non-divers.
- Authors
Delapille, Pascal; Verin, Eric; Tourny-Chollet, Claire; Pasquis, Pierre
- Abstract
Nitric oxide (NO) modulates transcription factors that bind specific cis-regulatory DNA responsible for coordinating the spatial and temporal patterns of gene expression that are initiated by a changing microenvironment. In this way NO helps to orchestrate gene transcription and forms the basis of functional cell responses to accommodate metabolic requirements and to coordinate endogenous defense mechanisms against a variety of stress and disease conditions. There is marked overlap between the signalling pathways triggered by NO, superoxide, and hypoxia. Understanding the redox-based regulation of signal transduction and gene expression will provide insights into how cell activities are constantly coordinated and how promising new therapies may be developed.
- Subjects
GENE expression; GENETIC regulation; ADENOSINE triphosphatase gene expression; CELLULAR mechanics; TRANSCRIPTION factors; DEFENSE mechanisms (Psychology)
- Publication
Pflügers Archiv: European Journal of Physiology, 2001, Vol 442, Issue 4, p588
- ISSN
0031-6768
- Publication type
Article
- DOI
10.1007/s004240100568