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- Title
The impact of musculoskeletal diseases on mortality-comparison with internal diseases: A 15-year longitudinal study.
- Authors
Kasai, Takehiro; Hasegawa, Yukiharu; Imagama, Shiro; Sakai, Tadahiro; Wakai, Kenji; Suzuki, Koji; Ishiguro, Naoki
- Abstract
<bold>Background: </bold>Aging is associated with an increased incidence of diabetes (DM), hypertension (HT), hyperlipidemia (HL), as well as musculoskeletal disorders, such as osteoarthritis (OA) and osteoporosis (OP). However, the impact of musculoskeletal disorders on mortality remains unclear. This study investigated the risk of mortality if having knee OA or OP.<bold>Methods: </bold>601 participants (mean age 67.8 ± 5.3 years) who underwent musculoskeletal check-ups in Yakumo town were enrolled in this study, 248 were males and 353 were females. The following parameters were assessed: age, sex, body mass index, smoking habit, alcohol drinking habit, physical exercise habit, knee OA, OP, HT, DM and HL. Kaplan-Meier survival curves for smoking, drinking and physical exercise habits, knee OA, OP, HT, DM and HL were prepared, and the log-rank test was performed. Furthermore, the Cox hazard model was used for multivariate analysis of all variables.<bold>Results: </bold>Knee OA, OP, HT, and DM were associated with a significantly higher mortality rate. Cox regression analysis results showed a hazard ratio of 1.972 for OA (95%CI: 1.356-2.867), 1.965 for DM (1.146-3.368), 1.706 for smoking habits (1.141-2.552), and 1.614 for OP (1.126-2.313). Cardiovascular diseases were the most common causes of death.<bold>Conclusions: </bold>Smoking, knee OA, OP and DM were all associated with increased risk of mortality. Knee OA had a high hazard ratio, comparable to that of DM. These findings suggest that interventions against smoking, knee OA, OP and DM may reduce the risk of mortality.
- Subjects
MUSCULOSKELETAL diseases in old age; DISEASE incidence; SMOKING; BODY mass index; MORTALITY; LONGITUDINAL method; DISEASE risk factors; CARDIOVASCULAR disease diagnosis; CARDIOVASCULAR disease related mortality; CARDIOVASCULAR disease treatment; DIAGNOSIS of diabetes; TREATMENT of diabetes; TREATMENT of musculoskeletal system diseases; RESPIRATORY disease diagnosis; TREATMENT of respiratory diseases; TUMOR treatment; AGING; COMPARATIVE studies; CAUSES of death; DEMOGRAPHY; DIABETES; RESEARCH methodology; MEDICAL cooperation; MULTIVARIATE analysis; MUSCULOSKELETAL system diseases; RESEARCH; RESPIRATORY diseases; RISK assessment; SURVIVAL analysis (Biometry); TUMORS; EVALUATION research; PROPORTIONAL hazards models; KAPLAN-Meier estimator
- Publication
Journal of Orthopaedic Science, 2017, Vol 22, Issue 6, p1126
- ISSN
0949-2658
- Publication type
journal article
- DOI
10.1016/j.jos.2017.06.014