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- Title
The Luteolinidin and Petunidin 3- O -Glucoside: A Competitive Inhibitor of Tyrosinase.
- Authors
Yang, Seo Young; Kim, Jang Hoon; Su, Xiangdong; Kim, Jeong Ah
- Abstract
The enzyme tyrosinase plays a key role in the early stages of melanin biosynthesis. This study evaluated the inhibitory activity of anthocyanidin (1) and anthocyanins (2–6) on the catalytic reaction. Of the six derivatives examined, 1–3 showed inhibitory activity with IC50 values of 3.7 ± 0.1, 10.3 ± 1.0, and 41.3 ± 3.2 μM, respectively. Based on enzyme kinetics, 1–3 were confirmed to be competitive inhibitors with Ki values of 2.8, 9.0, and 51.9 μM, respectively. Molecular docking analysis revealed the formation of a binary encounter complex between 1–3 and the tyrosinase catalytic site. Luteolinidin (1) and petunidin 3-O-glucoside (2) may serve as tyrosinase inhibitors to block melanin production.
- Subjects
PHENOL oxidase; ENZYME kinetics; MOLECULAR docking; ANTHOCYANINS; MELANINS; BIOSYNTHESIS
- Publication
Molecules, 2022, Vol 27, Issue 17, p5703
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27175703