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- Title
Effect of Korean Red Ginseng and Rg3 on Asian Sand Dust-Induced MUC5AC, MUC5B, and MUC8 Expression in Bronchial Epithelial Cells.
- Authors
Shin, Seung-Heon; Ye, Mi-Kyung; Lee, Dong-Won; Kang, Byung-Jun; Chae, Mi-Hyun; Pak, Sokcheon; Ooi, Soo Liang; Cuadrado, Carmen
- Abstract
Korean Red ginseng (KRG), commonly used in traditional medicine, has anti-inflammatory, anti- oxidative, and anti-tumorigenic properties. Asian sand dust (ASD) is known to aggravate upper and lower airway inflammatory responses. BEAS-2B cells were exposed to ASD with or without KRG or ginsenoside Rg3. Mucin 5AC (MUC5AC), MUC5B, and MUC8 mRNA and protein expression levels were determined using quantitative RT-PCR and enzyme-linked immunosorbent assay. Nuclear factor kappa B (NF-κB), activator protein 1, and mitogen-activated protein kinase expression and activity were determined using western blot analysis. ASD induced MUC5AC, MUC5B, and MUC8 mRNA and protein expression in BEAS-2B cells, which was significantly inhibited by KRG and Rg3. Although ASD-induced mucin expression was associated with NF-κB and p38 mitogen-activated protein kinase (MAPK) activity, KRG and Rg3 significantly suppressed only ASD-induced NF-κB expression and activity. KRG and Rg3 inhibited ASD-induced mucin gene expression and protein production from bronchial epithelial cells. These results suggest that KRG and Rg3 have potential for treating mucus-producing airway inflammatory diseases.
- Subjects
NF-kappa B; EPITHELIAL cells; AP-1 transcription factor; MITOGEN-activated protein kinases; GINSENG; MUCUS
- Publication
Molecules, 2021, Vol 26, Issue 7, p2002
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules26072002