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- Title
Eudesmane and Eremophilane Sesquiterpenes from the Fruits of Alpinia oxyphylla with Protective Effects against Oxidative Stress in Adipose-Derived Mesenchymal Stem Cells.
- Authors
Thapa, Punam; Lee, Yoo Jin; Nguyen, Tiep Tien; Piao, Donglan; Lee, Hwaryeong; Han, Sujin; Lee, Yeon Jin; Han, Ah-Reum; Choi, Hyukjae; Jeong, Jee-Heon; Nam, Joo-Won; Seo, Eun Kyoung; Sülsen, Valeria P.
- Abstract
Alpinia oxyphylla Miquel (Zingiberaceae) has been reported to show antioxidant, anti-inflammatory, and neuroprotective effects. In this study, two new eudesmane sesquiterpenes, 7α-hydroperoxy eudesma-3,11-diene-2-one (1) and 7β-hydroperoxy eudesma-3,11-diene-2-one (2), and a new eremophilane sesquiterpene, 3α-hydroxynootkatone (3), were isolated from the MeOH extract of dried fruits of A. oxyphylla along with eleven known sesquiterpenes (4–14). The structures were elucidated by the analysis of 1D/2D NMR, high-resolution electrospray ionization mass spectrometry (HRESIMS), and optical rotation data. Compounds (1–3, 5–14) were evaluated for their protective effects against tert-butyl hydroperoxide (tBHP)-induced oxidative stress in adipose-derived mesenchymal stem cells (ADMSCs). As a result, treatment with isolated compounds, especially compounds 11 and 12, effectively reverted the damage of tBHP on ADMSCs in a dose-dependent manner. In particular, 11 and 12 at 50 µM improved the viability of tBHP-toxified ADMSCs by 1.69 ± 0.05-fold and 1.61 ± 0.03-fold, respectively.
- Subjects
MESENCHYMAL stem cells; ELECTROSPRAY ionization mass spectrometry; OXIDATIVE stress; ALPINIA; SESQUITERPENES
- Publication
Molecules, 2021, Vol 26, Issue 6, p1762
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules26061762