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- Title
Antimicrobial O-Alkyl Derivatives of Naringenin and Their Oximes Against Multidrug-Resistant Bacteria.
- Authors
Duda-Madej, Anna; Kozłowska, Joanna; Krzyżek, Paweł; Anioł, Mirosław; Seniuk, Alicja; Jermakow, Katarzyna; Dworniczek, Ewa; Muñoz-Torrero, Diego
- Abstract
New antimicrobial agents are needed to address infections caused by multidrug-resistant bacteria. Here, we are reporting novel O-alkyl derivatives of naringenin and their oximes, including novel compounds with a naringenin core and O-hexyl chains, showing activity against clinical strains of clarithromycin-resistant Helicobacter pylori, vancomycin-resistant Enterococcus faecalis, methicillin-resistant Staphylococcus aureus, and beta-lactam-resistant Acinetobacter baumannii and Klebsiella pneumoniae. The minimum inhibitory concentrations (MICs), which provide a quantitative measure of antimicrobial activity, were in the low microgram range for the selected compounds. Checkerboard assays for the most active compounds in combination with antibiotics revealed interactions that varied from synergistic to neutral.
- Subjects
ACINETOBACTER baumannii; LACTAMS; OXIME derivatives; METHICILLIN-resistant staphylococcus aureus; HELICOBACTER pylori; BACTERIA; ENTEROCOCCUS faecalis; KLEBSIELLA pneumoniae
- Publication
Molecules, 2020, Vol 25, Issue 16, p3642
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25163642