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- Title
Synthesis of New Triarylpyrazole Derivatives Possessing Terminal Sulfonamide Moiety and Their Inhibitory Effects on PGE2 and Nitric Oxide Productions in Lipopolysaccharide-Induced RAW 264.7 Macrophages.
- Authors
Abdel-Maksoud, Mohammed S.; El-Gamal, Mohammed I.; Gamal El-Din, Mahmoud M.; Choi, Yunji; Choi, Jungseung; Shin, Ji-Sun; Kang, Shin-Young; Yoo, Kyung Ho; Lee, Kyung-Tae; Baek, Daejin; Oh, Chang-Hyun
- Abstract
This article describes the design, synthesis, and in vitro anti-inflammatory screening of new triarylpyrazole derivatives. A total of 34 new compounds were synthesized containing a terminal arylsulfonamide moiety and a different linker between the sulfonamide and pyridine ring at position 4 of the pyrazole ring. All the target compounds were tested for both cytotoxicity and nitric oxide (NO) production inhibition in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. Compounds 1b, 1d, 1g, 2a, and 2c showed the highest NO inhibition percentages and the lowest cytotoxic effect. The most potent derivatives were tested for their ability to inhibit prostaglandin E2 (PGE2) in LPS-induced RAW 264.7 macrophages. The IC50 for nitric oxide inhibition, PGE2 inhibition, and cell viability were determined. In addition, 1b, 1d, 1g, 2a, and 2c were tested for their inhibitory effect on LPS-induced inducible nitric oxide synthase (iNOS) and Cyclooxygenase 2 (COX-2) protein expression as well as iNOS enzymatic activity.
- Subjects
PYRAZOLE derivatives; FUNCTIONAL groups; PROSTAGLANDINS; MACROPHAGES; CYCLOOXYGENASE 2; PROTEIN expression; NITRIC-oxide synthases
- Publication
Molecules, 2018, Vol 23, Issue 10, p2556
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules23102556