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- Title
New Thiosemicarbazides and 1,2,4-Triazolethiones Derived from 2-(Ethylsulfanyl) Benzohydrazide as Potent Antioxidants.
- Authors
Nazarbahjat, Nafal; Nordin, Nurdiana; Abdullah, Zanariah; Ameen Abdulla, Mahmood; Yehye, Wageeh A.; Abdul Halim, Siti Nadiah; Chin Hui Kee; Ariffin, Azhar
- Abstract
New thiosemicarbazide derivatives 2-6 were synthesised by reacting 2-(ethylsulfanyl)benzohydrazide with various aryl isothiocyanates. The cyclisation of compounds 2-6 under reflux conditions in a basic medium (aqueous NaOH, 4 N) yielded compounds 7-11 that contain a 1,2,4-triazole ring. All of the synthesised compounds were screened for their antioxidant activities. Compounds 2, 3, and 7 showed better radical scavenging in a 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, with IC50 values of 1.08, 0.22, and 0.74 μg/mL, respectively, compared to gallic acid (IC50, 1.2 μg/mL). Compound 3 also showed superior results in a ferric reducing antioxidant power (FRAP) assay (3054 μM/100 g) compared to those of ascorbic acid (1207 μM/100 g).
- Subjects
CHEMICAL derivatives; TRIAZOLES; SULFIDES; X-rays; ANTIOXIDANTS
- Publication
Molecules, 2014, Vol 19, Issue 8, p11520
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules190811520