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- Title
Pancreatic Lipase Inhibitory Gallotannins from Galla Rhois with Inhibitory Effects on Adipocyte Differentiation in 3T3-L1 Cells.
- Authors
O. Jun Kwon; Jong-Sup Bae; Ha Yeong Lee; Ju-Young Hwang; Eun-Woo Lee; Hideyuki Ito; Tae Hoon Kim
- Abstract
Activity-guided isolation of a methanolic extract of Galla Rhois using pancreatic lipase and 3T3-L1 adipocytes led to the isolation of seven phenolic compounds: protoaphin-fβ (1), 2-O-digalloyl-1,3,4,6-tetra-O-galloyl-β-D-glucose (2), 1,2,3,4,6-penta-O-galloyl-β-D-glucose (3), 1,2,4,6-tetra-O-galloyl-β-D-glucose (4), 3-hydroxy-5-methoxy-phenol 1-O-β-D-glucoside (5), methylgallate (6), and gallic acid (7). Their structures were estaβlished on the βasis of NMR and MS spectroscopic data interpretation. All isolates were evaluated for their inhiβitory effects on pancreatic lipase, and compounds 1-5 exhiβited potent inhiβitory effects on this enzyme, with IC50 values ranging from30.6 ± 2.4 to 3.5 ± 0.5 mM. In addition, the highly galloylated compound 2 was also found to induce potent inhiβition of adipocyte differentiation in 3T3-L1 cells.
- Subjects
GALLOTANNIN; FAT cells; PHENOLS; METHANOL; GLUCOSIDES
- Publication
Molecules, 2013, Vol 18, Issue 9, p10629
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules180910629