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- Title
Immunostimulatory Effect of Laminarin on RAW 264.7 Mouse Macrophages.
- Authors
Ji Young Lee; Young-Jin Kim; Hyun Joo Kim; Yoon-Sang Kim; Wansu Park
- Abstract
This study investigated the immunostimulatory effects of laminarin with respect to inflammatory mediators such as hydrogen peroxide, calcium, nitric oxide, various cytokines, transcription factors, and immune response gene in RAW 264.7 mouse macrophages. Laminarin did not reduce the cell proliferation of RAW 264.7 mouse macrophages at concentrations up to 500 μg/mL. Laminarin significantly increased the release of hydrogen peroxide, calcium, nitric oxide, monocyte chemotactic protein-1, vascular endothelial growth factor, leukemia inhibitory factor, and granulocyte-colony stimulating factor with enhancing expression of Signal Transducer and Activator of Transcription 1 (STAT1), STAT3, c-Jun, c-Fos, and cyclooxygenase-2 mRNA in RAW 264.7 cells. The results suggest that laminarin has immunostimulatory properties, strengthening immune reactions via the transcription factor pathway in macrophages.
- Subjects
MACROPHAGES; HYDROGEN peroxide; NITRIC oxide; CYTOKINES; TRANSCRIPTION factors; IMMUNE response; CHEMOTACTIC factors
- Publication
Molecules, 2012, Vol 17, Issue 5, p5404
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules17055404