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- Title
The impact of p16<sup>ink4a</sup> positivity in invasive vulvar cancer on disease-free and disease-specific survival, a retrospective study.
- Authors
Gensthaler, Lisa; Joura, Elmar A.; Alemany, Laia; Horvat, Reinhard; de Sanjosé, Silvia; Pils, Sophie
- Abstract
<bold>Purpose: </bold>To evaluate HPV and p16ink4a status as prognostic factors in patients with invasive vulvar cancer.<bold>Methods: </bold>Retrospective analysis of disease-free (DFS) and disease-specific survival (DSS) of patients with invasive vulvar cancer at a single tertiary care center. Histology, HPV and p16ink4a status were evaluated in the context of a global multicenter trial. Logistic regression models were performed to identify the impact of p16ink4a positivity.<bold>Results: </bold>135 patients were included in the analysis. 32 (23.7%) showed a p16ink4a expression of over 25%. Disease-free and disease-specific survival was longer in p16ink4a positive patients (23 vs. 10 months, p = 0.004, respectively, 29 vs. 21 months, p = 0.016). In multivariate analysis, p16ink4a positivity was an independent parameter for DFS (p = 0.025, HR: 2.120 (1.100-4.085)), but not for DSS (p = 0.926, HR: 1.029 (0.558-1.901), in contrast to age and tumor stage.<bold>Conclusions: </bold>Age and tumor stage negatively affect survival. However, disease-free survival is significantly longer in patients with p16ink4a positive invasive vulvar cancer.
- Subjects
VULVAR cancer; PROGRESSION-free survival; TUMOR classification; MULTIVARIATE analysis; REGRESSION analysis; PROTEIN metabolism; RESEARCH; RESEARCH methodology; VULVAR tumors; PROGNOSIS; RETROSPECTIVE studies; EVALUATION research; MEDICAL cooperation; COMPARATIVE studies; SURVIVAL analysis (Biometry)
- Publication
Archives of Gynecology & Obstetrics, 2020, Vol 301, Issue 3, p753
- ISSN
0932-0067
- Publication type
journal article
- DOI
10.1007/s00404-020-05431-7