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- Title
Effect on Urapidil on Benign Prostatic Hypertrophy: A Multicenter, Double-Blind Study.
- Authors
Kawabe, K.; Tsuchida, S.; Shimazaki, J.; Morita, T.; Yasuda, K.; Kageyama, S.
- Abstract
In a prospective multicentric double-blind trial, urapidil, an α1-adrenergic antagonist, was investigated for its efficacy in benign prostatic hypertrophy (BPH). After 1 week of baseline on placebo, 214 patients with BPH were randomly assigned to 4 groups; group P was given placebo, group L, 15 mg of urapidil b.i.d. for 3 weeks, group M, 15 mg b.i.d. for 1 week followed by 30 mg b.i.d. for 2 weeks, and group H, 15 mg b.i.d. for 1 week followed by 45 mg b.i.d. for 2 weeks. In all groups, day and night urinary frequency improved significantly (p < 0.01 or p < 0.05) compared to baseline, but the differences were not significant between groups. The residual urine rate was significantly (p < 0.05 vs. group P) decreased in group H. Average and maximum flow rate improved significantly (p < 0.01 or p < 0.05) in group M and group H, but intergroup differences were not noted. Overall impression evaluated by investigators improved significantly (p < 0.01 vs. group P) in group M and group H. More patients in group H (7/55) and group M (4/51) had side effects than in group P (2/54). None of them were severe. In summary, a daily dosage of 60 mg urapidil proved to be the most beneficial in the treatment of patients with BPH. Copyright © 1993 S. Karger AG, Basel
- Publication
Urologia Internationalis, 1993, Vol 50, Issue 1, p27
- ISSN
0042-1138
- Publication type
Article
- DOI
10.1159/000282443