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- Title
Features of the Free Radical Oxidation Process and Antioxidant System in Newborns Born to HIV-Infected of Mothers Who Received Antiretroviral Therapies to Prevent HIV Transmission.
- Authors
Kurashova, N. A.; Vanyarkina, A. S.; Petrova, A. G.; Rychkova, L. V.; Kolesnikov, S. I.; Darenskaya, M. A.; Moskaleva, E. V.; Kolesnikova, L. I.
- Abstract
The LPO processes and the state of the antioxidant system in perinatally HIV-exposed newborns were studied. Perinatally HIV-exposed (n=62) and healthy newborns (n=80; control) were examined retrospectively (Apgar score 8 in both groups). Blood plasma and erythrocyte hemolysate were used as the material for biochemical tests. Using spectrophotometric, fluorometric, and statistical methods, we found enhanced LPO processes insufficiently compensated by the antioxidant system with excessive accumulation of damaging metabolites in the blood of perinatally HIV-exposed newborns. These changes can be a consequence of oxidative stress during the perinatal period.
- Subjects
HIV infection transmission; FREE radicals; NEWBORN infants; ANTIRETROVIRAL agents; MOTHERS; HIV
- Publication
Bulletin of Experimental Biology & Medicine, 2023, Vol 174, Issue 4, p413
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-023-05719-z