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- Title
Growth of Mesenchymal Stem Cells on Poly(3-Hydroxybutyrate) Scaffolds Loaded with Simvastatin.
- Authors
Akoulina, E. A.; Demianova, I. V.; Zharkova, I. I.; Voinova, V. V.; Zhuikov, V. A.; Khaydapova, D. D.; Chesnokova, D. V.; Menshikh, K. A.; Dudun, A. A.; Makhina, T. K.; Bonartseva, G. A.; Volkov, A. V.; Asfarov, T. F.; Ivanov, S. Y.; Shaitan, K. V.; Bonartsev, A. P.
- Abstract
We studied the effect of porous composite scaffolds based on poly(3-hydroxybutyrate) (PHB) loaded with simvastatin on the growth and differentiation of mesenchymal stem cells. The scaffolds have a suitable microstructure (porosity and pore size) and physicochemical properties to support the growth of mesenchymal stem cells. Scaffold loading with simvastatin suppressed cell growth and increased alkaline phosphatase activity, which can attest to their osteoinductive properties.
- Subjects
MESENCHYMAL stem cells; SIMVASTATIN; 3-Hydroxybutyric acid; MESENCHYMAL stem cell differentiation; TISSUE scaffolds; ALKALINE phosphatase; POLYHYDROXYBUTYRATE; POLY-beta-hydroxybutyrate
- Publication
Bulletin of Experimental Biology & Medicine, 2021, Vol 171, Issue 1, p172
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-021-05190-8