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- Title
Functional State of Various Types of Regeneration-Competent Cells in the Nervous Tissue in Ethanol-Induced Neurodegeneration.
- Authors
Zyuz'kov, G. N.; Miroshnichenko, L. A.; Udut, E. V.; Chaikovskii, A. V.; Polyakova, T. Yu.; Simanina, E. V.; Stavrova, L. A.; Agafonov, V. I.; Zhdanov, V. V.
- Abstract
The in vitro and in vivo models of ethanol-induced neurodegeneration were used to evaluate the content and functional activity of various types of regeneration-competent cells in subventricular zone of the cerebral hemispheres in C57Bl/6JY mice. In nervous tissue culture, ethanol (65 mM) produced no effect on formation of neurospheres. When administered per os in a daily dose of 3 g/kg for 8 weeks, ethanol produced no effect on the number of neural CFU in situ. In both cases, ethanol reduced proliferative activity of neural CFU. Long-term administration of ethanol in vivo suppressed differentiation of neural stem cells and decreased the number of committed precursors (neural cluster-forming units) in the subventricular zone of cerebral hemispheres. In vitro application of ethanol stimulated secretion of humoral growth factors by the cluster-forming neural glial cells. In contrast, in vivo administration of ethanol suppressed this secretion.
- Subjects
NERVE tissue; CEREBRAL hemispheres; NEURAL stem cells; NEURODEGENERATION; NEUROGLIA; TISSUE culture
- Publication
Bulletin of Experimental Biology & Medicine, 2019, Vol 166, Issue 6, p317
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-019-04341-2