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- Title
Comparative Study of the Severity of Renal Damage in Newborn and Adult Rats under Conditions of Ischemia/Reperfusion and Endotoxin Administration.
- Authors
Pevzner, I. B.; Pavlenko, T. A.; Popkov, V. A.; Andrianova, N. V.; Zorova, L. D.; Brezgunova, A. A.; Zorov, S. D.; Yankauskas, S. S.; Silachev, D. N.; Zorov, D. B.; Plotnikov, E. Yu.
- Abstract
Oxidative kidney injury was compared in newborn and adult rats under conditions of ischemia/reperfusion and in experimental model of systemic inflammation induced by endotoxin (LPS of bacterial cell wall) administration. Oxidative stress in the kidney accompanied both experimental models, but despite similar oxidative tissue damage, kidney dysfunction in neonates was less pronounced than in adult animals. It was found that neonatal kidney has a more potent regenerative potential with higher level of cell proliferation than adult kidney, where the level proliferating cell antigen (PCNA) increased only on day 2 after ischemia/reperfusion. The pathological process in the neonatal kidney developed against the background of active cell proliferation, and, as a result, proliferating cells could almost immediately replace the damaged structures. In the adult kidney, regeneration of the renal tissue was activated only after significant loss of functional nephrons and impairment of renal function.
- Subjects
ENDOTOXIN analysis; LABORATORY rats; PROLIFERATING cell nuclear antigen; NUCLEAR proteins; NEPHRONS
- Publication
Bulletin of Experimental Biology & Medicine, 2018, Vol 165, Issue 2, p189
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-018-4127-5