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- Title
Reinforced Hybrid Collagen Sponges for Tissue Engineering.
- Authors
Bardakova, K. N.; Grebenik, E. A.; Istranova, E. V.; Istranov, L. P.; Gerasimov, Yu. V.; Grosheva, A. G.; Zharikova, T. M.; Minaev, N. V.; Shavkuta, B. S.; Dudova, D. S.; Kostyuk, S. V.; Vorob'eva, N. N.; Bagratashvili, V. N.; Timashev, P. S.; Chailakhyan, R. K.
- Abstract
We created an anisotropic material based on collagen sponge and reactive polylactide structured by laser photopolymerization. The combination of collagen with reactive polylactide improves the resistance of the formed matrices to biodegradation in comparison with collagen sponge, while the existence of sites with different mechanical characteristics and cell affinity on the matrix provides directed cell growth during their culturing. It was shown that reinforcement of the collagen sponges 7-fold increased the mean Young's modulus for the hybrid matrix without affecting its cytotoxicity. The developed matrix provides cell adhesion and proliferation along reinforcement lines and can be used for fabrication of tissue engineering constructs.
- Subjects
COLLAGEN; TISSUE scaffolds; REGENERATIVE medicine; CONNECTIVE tissues; BIOMATERIALS
- Publication
Bulletin of Experimental Biology & Medicine, 2018, Vol 165, Issue 1, p142
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-018-4116-8