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- Title
Effect of Hedgehog Signaling Pathway Activation on Proliferation of High-Grade Gliomas.
- Authors
Cherepanov, S.; Cherepanova, K.; Grinenko, N.; Antonova, O.; Chekhonin, V.
- Abstract
We studied the effect of an activator (ShTh) and an inhibitor (cyclopamine) of the Hedgehog signaling pathway on proliferation of human glioma cell lines U87-MG and U251-MG and cultured human astrocytes. The Hedgehog signaling pathway is activated in glioma cells, but not in cultured human astrocytes. Experiments with Shh and cyclopamine can serve as an additional criterion for assessing activity of Hedgehog signaling in known cell lines and primary cultured cells.
- Subjects
GLIOMAS; CELL proliferation; CELL lines; HEDGEHOG signaling proteins; CYCLOPAMINE; ASTROCYTES
- Publication
Bulletin of Experimental Biology & Medicine, 2016, Vol 161, Issue 5, p674
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-016-3483-2