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- Title
Associations between Vitamin D-Binding Protein ( DBP) Gene Polymorphism (TAAA)n and Development of Osteoporosis in the Volga-Ural Region of Russia.
- Authors
Khusainova, R.; Seleznyova, L.; Mal'tsev, A.; Shakirova, R.; Nurlygayanov, R.; Nadyrshina, D.; Khusnutdinova, E.
- Abstract
Study of DBP gene (TAAA) polymorphism in women of postmenopausal age revealed a significantly lower incidence of DBP 10 allele and a higher incidence of DBP 11 allele in Russian women with bone fractures in comparison with the relevant controls (χ = 4.47, p = 0.034 and χ = 4.28, p = 0.038, respectively). Allele DBP 11 is a high risk marker (OR = 1.93; 95%CI 1.06-3.48), while allele DBP10 a marker of low risk of bone fractures (OR = 0.59; 95%CI 0.37-0.94). A trend to a reduction of mineral density of the femoral neck and of the lumbar vertebrae in women with DBP 10 8 genotype of DBP gene polymorphic locus (TAAA) in comparison with DBP 10 10 and DBP 10 11 genotype carriers is traced.
- Subjects
VOLGA-Ural Region (Russia); GENETIC polymorphism research; VITAMIN D-binding proteins; OSTEOPOROSIS in women; BONE fractures; ALLELES; BONE density; GENETICS
- Publication
Bulletin of Experimental Biology & Medicine, 2014, Vol 157, Issue 2, p253
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-014-2538-5