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- Title
Study of Anti-Ischemic Effect of Afobazole in Experimental Myocardial Infarction.
- Authors
Kryzhanovskyi, S.; Sorokina, A.; Stolyaruck, V.; Vititnova, M.; Miroshkina, I.; Tsorin, I.; Durnev, A.; Seredenin, S.
- Abstract
Seven-day treatment of rats with experimental myocardial infarction with afobazole (5-ethoxy-2-[2-morpholino)-ethylthio] benzimidasole dihydrochloride) resulted in shrinkage of the ischemic damage area in the heart, stimulation of reparative processes in the myocardium, and prevention of postinfarction remodeling of the left ventricle. Anti-ischemic effect of afobazole in experimental myocardial infarction is presumably due to its interactions with σ receptors.
- Subjects
MYOCARDIAL infarction treatment; RATS; ISCHEMIA; THERAPEUTICS; HEART diseases; URETHANE
- Publication
Bulletin of Experimental Biology & Medicine, 2010, Vol 150, Issue 3, p316
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-011-1131-4