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- Title
Evaluation of Immunotherapy Efficiency in Mouse CaO-1 Ovarian Carcinoma Treated by Vaccines Based on Dendritic Cells.
- Authors
S. Sitdikova; M. Kiselevskii; V. Selâchuk; B. Amandzholov; E. Kurbatova; F. Donenko
- Abstract
Injection of dendritic cells, pulsated by tumor lysate or mucin, containing CA 125 antigen, led to a more than 50% inhibition of tumor growth in female CBA mice with transplanted mouse pseudomucinous CaO-1 ovarian carcinoma in comparison with the control. Tumor-associated CA 125 antigen can be used for obtaining dendritic cell vaccines against ovarian malignant tumors. This trend will extend the potentialities of application of antitumor vaccines based on dendritic cells, as clinical use of this technology is limited by the need in patientâs tumor material. Mucin, containing Ca 125 antigen, can be isolated from patientâs serum or obtained by gene engineering technologies as a recombinant peptide.
- Subjects
OVARIAN cancer; CANCER immunotherapy; TREATMENT effectiveness; LABORATORY mice; CANCER vaccines; DENDRITIC cells; TUMOR growth prevention; TUMOR antigens
- Publication
Bulletin of Experimental Biology & Medicine, 2009, Vol 147, Issue 2, p226
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-009-0480-8